Now certainly, large enterprises and especially security sensitive ones requiring secure access to and transmission of data such as financial services, R&D, law enforcement and others do require a higher level of attention to detail when designing and operating their systems. Most engineers cut their teeth building systems in the privacy of their homes or labs, neither of which can match the scale and complexity of real-world systems spanning continents, regulatory domains and most importantly untrusted links. When learning and experimenting, the engineer tends to be in control of everything.
Secure authentication is enabled by default in Windows, with Kerberos providing one of the most resilient systems available, and AD integration makes expansion and administration a breeze. But most of the remaining protocols don't pay too much attention, starting with the most pervasive - CIFS (Windows File Sharing). Even RDP starts off with secure authentication then moves on to a plaintext stream for keyboard inputs and screen updates.
I'm a big fan of IPSec, since it allows for transparent encryption and authentication without having to do pretty much anything to your applications or network layout. The problem comes in getting all your nodes to play nice, since it does require some configuration. Windows domain policies and domain membership vastly simplifies this - if your system is a domain member, enabling opportunistic IPSec encryption is a breeze.
This is the "Defined Domain", a set of systems over which you have complete control. A visitor to your network would not have these policies defined, so their device would not be able to participate, but placing them in a guest LAN and tunneling the connection at the router over a secure connection in Tunnel mode can help solve that problem, but it can quickly spiral out from there - how do you get simpler devices and protocols like SNMP and even PING to cooperate?
The Defined Domain needs to incorporate not just the systems you're protecting, but also how and why. Secure protocols aren't that hard to come by these days (e.g. SNMPv3 incorporates some measure of encryption, SSL is available in all major web platforms), but still requires some configuration and attention. Applications need to be designed with at least some measure of awareness of the security domain if they are to be trusted, and administrators and designers most of all need to keep this in their head when going about their work.
The biggest threat to any security domain is and will always be the human factor. By incorporating security devices in an easy-to-use package, and often transparent, it can make the average engineer immune to the considerations required to make systems truly secure. Yet again, ease induces laziness, and the worst kind of security is the kind you can't (or won't) verify. It took about two hours of use before a colleague of mine noticed his newly-secured RDP session (certificate-based authentication) placed a new padlock symbol on the control bar of his Terminal Services Client. Until then, the idea that the connection was relatively more secure was fairly unverifiable, and eventually irrelevant.
Attention is required, and a lot of education. No one security solution is a panacea (everyone kept screaming certificates at me, as a one-size fits all solution, no no no), and this will always be the problem.
At least in a defined domain, it's more manageable, more approachable. And then along come the users...